Raman spectroscopy is based on the phenomenon of Raman scattering, which obtains chemical and structural information by measuring the scattering spectra generated by molecular vibrations in samples, such as biomolecules, cells, tissues, and organs. Its biomarkers are various biological fluids, such as urine, saliva, blood, and tears. Analyzing and evaluating selected biomarkers can represent the relationship between Raman scattering spectral indicators and clinical conditions. Raman spectroscopy, as a non-destructive spectroscopic technique, is widely used in the chemical and pharmaceutical industries The following is a detailed explanation of several applications of Raman spectroscopy in the chemical and pharmaceutical industry:

1.Drug development and quality control:Raman spectroscopy can be used in various stages of drug development, including drug discovery, drug optimization, and quality control during drug formulation processes. By using Raman spectroscopy, the molecular structure, chemical composition, and purity of drugs can be quickly determined, as well as monitoring the changes in drug preparation processes and the generation of decomposition products.

2. Identification of counterfeit drugs: Raman spectroscopy can be used for rapid identification and detection of counterfeit drugs. Due to the unique Raman spectral fingerprints of each drug, counterfeit drugs can be identified by comparing them with genuine ones. This is crucial for ensuring the quality and safety of drugs, especially in areas where distribution channels are not perfect or counterfeit drugs are prone to occur.

3. Component analysis: Raman spectroscopy can be used for the analysis of various components in drugs. For complex pharmaceutical formulations, Raman spectroscopy can provide fast and accurate component analysis results without the need for expensive sample preparation processes. This helps to monitor the content of ingredients in drug formulations, detect possible impurities or impurities, and determine consistency between batches.

4. Crystal morphology analysis: The crystal morphology of drugs has a significant impact on their performance and stability. Raman spectroscopy can be used to characterize the structure and morphology of drug crystals. By observing the position and intensity of characteristic peaks in Raman spectroscopy, it is possible to infer the molecular arrangement and lattice structure in the crystal, as well as characterize the polycrystalline morphology or isomers of the crystal.

5. Process control: Raman spectroscopy can also be used for real-time monitoring and control in chemical drug manufacturing processes. Real time monitoring and control of reaction processes, mixing processes, and drying processes can be achieved through online or near-line Raman spectroscopy measurements to ensure that products meet expected quality standards and maximize production efficiency.