The Raman detection of cell culture plates system can automatically test and analyze the intracellular and extracellular components of each sample in each pore. It can achieve high-throughput and fully automated testing of a large number of samples by automatically replacing the porous plates through a robotic arm, without the need for manual operation. It is particularly suitable for parallel reactors and strain screening, and can also be used for rapid testing of samples from multiple fermentation tanks in factories, saving labor, improving testing efficiency, and accelerating the development time of products.