What is Raman technology

Introduction to Raman fingerprint spectroscopy technology

When a molecule is irradiated by a laser and scatters photons, a small amount of scattered light has a wavelength different from the incident light, which is called Raman photons. The Raman fingerprint peaks of different wavelengths originate from the interaction between light and sample molecular groups.

什么是拉曼技术

什么是拉曼技术

  • The Raman fingerprint spectrum is clear, and the material groups can be clearly labeled

  • Weak water Raman peak

  • Especially suitable for quantitative analysis of aqueous solution components

  • Can test OD, various acids, alcohols, fats, proteins, etc. (excluding metal ions)

  • Detection limit：50-100mg/L

Real time online analysis of biological processes

什么是拉曼技术


Role and advantagesApplication scope

  • Provide real-time information on bioreactors

  • Real time detection of process deviations to help achieve process control

  • Real time identification and optimization of biological processes to maximize production

  • No need for sampling and tedious sample preparation

  • Avoid disrupting the process and process group

  • Reduce pollution wind

  • Reduce manufacturing costs

  • Key matrix components, metabolites, products, and cell density testing during upstream fermentation and cell culture processes

  • Downstream purification process, including protein crystallization dissolution and product purification

  • Enzymatic conversion of biological processes and product matrices

  • Monitoring of biological and chemical reaction components


Upstream Cell Culture/Fermentation PAT Solution

什么是拉曼技术

The online Raman analyzer can test the Raman signals of intracellular and extracellular substances such as sugars, acids, alcohols, cell density, ammonium ions, and inorganic salts in real-time. Then, accurate biochemical parameter prediction models can be established through multivariate analysis or machine learning algorithms, enabling real-time prediction and display of various parameters in the next biological process. Through the OPC network protocol, data is transmitted to the controller. The controller establishes a control strategy for biochemical parameters according to customer requirements, completes closed-loop control, and achieves real-time monitoring requirements for biochemical parameters.